Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Drosophila cbl is essential for control of cell death and cell differentiation during eye development.

PloS one - 16 Jan 2008

Wang Yuan, Werz Christian, Xu Dongbin, Chen Zhihong, Li Ying, Hafen Ernst, Bergmann Andreas

Abstract excerpt

BACKGROUND: Activation of cell surface receptors transduces extracellular signals into cellular responses such as proliferation, differentiation and survival. However, as important as the activation of these receptors is their appropriate spatial and temporal down-regulation for normal development and tissue homeostasis. The Cbl family of E3-ubiquitin ligases plays a major role for the ligand-dependent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Cell Differentiation
Share to Drosophila

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drosophila Proteins

Share to ErbB Receptors

Share to Immunohistochemistry

Share to Proto-Oncogene Proteins c-cbl

Source

Open in PubMed Open full text

Identifiers

PMID: 18197257
DOI: 10.1371/journal.pone.0001447
PMCID: PMC2180199

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Drosophila cbl is essential for control of cell death and cell differentiation during eye development.PMID 18197257Read ↗

Regulation of EGFR and Notch signaling by distinct isoforms of D-cbl during Drosophila development.Semantic proximity Read ↗

Differential effects of Cbl isoforms on Egfr signaling in Drosophila.Semantic proximity Read ↗

A Drosophila analogue of v-Cbl is a dominant-negative oncoprotein in vivo.Semantic proximity Read ↗

The evolutionarily conserved N-terminal region of Cbl is sufficient to enhance down-regulation of the epidermal growth factor receptor.Semantic proximity Read ↗

c-Cbl ubiquitinates the EGF receptor at the plasma membrane and remains receptor associated throughout the endocytic route.Semantic proximity Read ↗

Cbl-mediated ubiquitinylation is required for lysosomal sorting of epidermal growth factor receptor but is dispensable for endocytosis.Semantic proximity Read ↗

Cullin-4 regulates Wingless and JNK signaling-mediated cell death in the Drosophila eye.Semantic proximity Read ↗

The Cbl RING finger C-terminal flank controls epidermal growth factor receptor fate downstream of receptor ubiquitination.Semantic proximity Read ↗

c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor.Semantic proximity Read ↗

D-cbl, a negative regulator of the Egfr pathway, is required for dorsoventral patterning in Drosophila oogenesis.Semantic proximity Read ↗

Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation.Semantic proximity Read ↗

Requirements of multiple domains of SLI-1, a Caenorhabditis elegans homologue of c-Cbl, and an inhibitory tyrosine in LET-23 in regulating vulval differentiation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.