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Article

Role of MRP4 (ABCC4) in platelet adenine nucleotide-storage: evidence from patients with delta-storage pool deficiencies.

The American journal of pathology - 1 Mar 2010

Jedlitschky Gabriele, Cattaneo Marco, Lubenow Lena E, Rosskopf Dieter, Lecchi Anna, Artoni Andrea, Motta Giovanna, Niessen Juliane, Kroemer Heyo K, Greinacher Andreas

Abstract excerpt

We previously showed that the MRP4 (ABCC4) transporter is expressed in human platelet delta-granules and may be involved in ADP transport. We now demonstrate by immunoblotting and immunofluorescence microscopy that platelet MRP4 is absent in two patients with a platelet delta-storage pool deficiency (delta-SPD)-like phenotype with reduced platelet adenine nucleotide (AN) but normal serotonin levels, whereas their...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20133816
DOI: 10.2353/ajpath.2010.090425
PMCID: PMC2832132

Genes

ABCC4
LAMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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