Article
The Slc35d3 gene, encoding an orphan nucleotide sugar transporter, regulates platelet-dense granules.
Blood - 15 Feb 2007
Chintala Sreenivasulu, Tan Jian, Gautam Rashi, Rusiniak Michael E, Guo Xiaoli, Li Wei, Gahl William A, Huizing Marjan, Spritz Richard A, Hutton Saunie, Novak Edward K, Swank Richard T
Abstract excerpt
Platelet dense granules are lysosome-related organelles which contain high concentrations of several biologically important low-molecular-weight molecules. These include calcium, serotonin, adenine nucleotides, pyrophosphate, and polyphosphate, which are necessary for normal blood hemostasis. The synthesis of dense granules and other lysosome-related organelles is defective in inherited diseases such as...
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