Article
Myeloid cell function in MRP-14 (S100A9) null mice.
Molecular and cellular biology - 1 Apr 2003
Hobbs Josie A R, May Richard, Tanousis Kiki, McNeill Eileen, Mathies Margaret, Gebhardt Christoffer, Henderson Robert, Robinson Matthew J, Hogg Nancy
Abstract excerpt
Myeloid-related protein 14 (MRP-14) and its heterodimeric partner, MRP-8, are cytosolic calcium-binding proteins, highly expressed in neutrophils and monocytes. To understand the function of MRP-14, we performed targeted disruption of the MRP-14 gene in mice. MRP-14(-/-) mice showed no obvious phenotype and were fertile. MRP-8 mRNA but not protein is present in the myeloid cells of these mice, suggesting that the...
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