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Article

Differential endosomal sorting of a novel P2Y12 purinoreceptor mutant.

Traffic (Copenhagen, Denmark) - 1 May 2013

Cunningham Margaret R, Nisar Shaista P, Cooke Alexandra E, Emery Elizabeth D, Mundell Stuart J

Abstract excerpt

P2Y12 receptor internalization and recycling play an essential role in ADP-induced platelet activation. Recently, we identified a patient with a mild bleeding disorder carrying a heterozygous mutation of P2Y12 (P341A) whose P2Y12 receptor recycling was significantly compromised. Using human cell line models, we identified key proteins regulating wild-type (WT) P2Y12 recycling and investigated P2Y12 -P341A...

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Share to Adenosine Diphosphate
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23387322
DOI: 10.1111/tra.12054

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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