Article
The role of Rab38 in platelet dense granule defects.
Journal of thrombosis and haemostasis : JTH - 1 Dec 2008
Ninkovic I, White J G, Rangel-Filho A, Datta Y H
Abstract excerpt
BACKGROUND: The fawn-hooded hypertensive (FHH) rat has a mutation in the Rab38 gene that is associated with a platelet dense granule storage pool disease. OBJECTIVE: To better characterize the expression and function of Rab38 in FHH rat and human megakaryocytes and platelets. PATIENTS AND METHODS: Rab38 expression in FHH rat and normal tissues was demonstrated by western blotting. Platelet and megakaryocyte...
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