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Article

Mutation of His 834 in human anion exchanger 1 affects substrate binding.

Biochimica et biophysica acta - 1 May 2010

Takazaki Shinya, Abe Yoshito, Yamaguchi Tomohiro, Yagi Mikako, Ueda Tadashi, Kang Dongchon, Hamasaki Naotaka

Abstract excerpt

Anion exchanger 1 (AE1 or band 3) is responsible for Cl(-)-HCO3(-) exchange on erythrocyte membrane. Previously, we showed that band 3 is fixed in an inward-facing conformation by specific modification of His 834 with DEPC, resulting in a strong inhibition of its anion transport activity. To clarify the physiological role of His 834, we evaluated the sulfate transport activities of various band 3 mutants:...

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Identifiers

PMID: 20132789
DOI: 10.1016/j.bbamem.2010.01.019

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