Article
Review. Leaky Cl--HCO3- exchangers: cation fluxes via modified AE1.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 27 Jan 2009
Ellory J C, Guizouarn H, Borgese F, Bruce L J, Wilkins R J, Stewart G W
Abstract excerpt
The abundant membrane protein AE1 normally functions as an obligate anion exchanger, with classical carrier properties, in human red blood cells. Recently, four single point mutations of hAE1 have been identified that have lost the anion exchange function, and act as non-selective monovalent cation channels, as shown in both red cell flux and oocyte expression studies. The red cell transport function shows a...
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