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Article

Crystal structure of the anion exchanger domain of human erythrocyte band 3.

Science (New York, N.Y.) - 6 Nov 2015

Arakawa Takatoshi, Kobayashi-Yurugi Takami, Alguel Yilmaz, Iwanari Hiroko, Hatae Hinako, Iwata Momi, Abe Yoshito, Hino Tomoya, Ikeda-Suno Chiyo, Kuma Hiroyuki, Kang Dongchon, Murata Takeshi, Hamakubo Takao, Cameron Alexander D, Kobayashi Takuya, Hamasaki Naotaka, Iwata So

Abstract excerpt

Anion exchanger 1 (AE1), also known as band 3 or SLC4A1, plays a key role in the removal of carbon dioxide from tissues by facilitating the exchange of chloride and bicarbonate across the plasma membrane of erythrocytes. An isoform of AE1 is also present in the kidney. Specific mutations in human AE1 cause several types of hereditary hemolytic anemias and/or distal renal tubular acidosis. Here we report the...

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Identifiers

PMID: 26542571
DOI: 10.1126/science.aaa4335

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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