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Article

Hepatitis C virus genotype-3a core protein enhances sterol regulatory element-binding protein-1 activity through the phosphoinositide 3-kinase-Akt-2 pathway.

The Journal of general virology - 1 Jun 2010

Jackel-Cram Candice, Qiao Ling, Xiang Zhongua, Brownlie Robert, Zhou Yan, Babiuk Lorne, Liu Qiang

Abstract excerpt

Hepatitis C virus genotype-3a (HCV-3a) is directly linked to the development of steatosis. We previously showed that, through sterol regulatory element binding protein-1 (SREBP-1), HCV-3a core protein upregulates the promoter activity of fatty acid synthase, a major enzyme involved in de novo lip...

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Source

Identifiers

PMID: 20130133
DOI: 10.1099/vir.0.017418-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20130133-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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