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Article

Down-regulation of phosphatase and tensin homolog by hepatitis C virus core 3a in hepatocytes triggers the formation of large lipid droplets.

Hepatology (Baltimore, Md.) - 1 Jul 2011

Clément Sophie, Peyrou Marion, Sanchez-Pareja Andrea, Bourgoin Lucie, Ramadori Pierluigi, Suter David, Vinciguerra Manlio, Guilloux Kevin, Pascarella Stephanie, Rubbia-Brandt Laura, Negro Francesco, Foti Michelangelo

Abstract excerpt

UNLABELLED: Hepatitis C virus (HCV) perturbs the host's lipid metabolism and often results in hepatic steatosis. In nonalcoholic fatty liver disease, the intrahepatic down-regulation of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a critical mechanism leading to steatosis and its progression toward fibrosis and hepatocellular carcinoma. However, whether an HCV infection triggers the formation...

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Source

Identifiers

PMID: 21465511
DOI: 10.1002/hep.24340

Genes

PTEN
IRS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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