Article
An in vitro model of hepatitis C virus genotype 3a-associated triglycerides accumulation.
Journal of hepatology - 1 May 2005
Abid Karim, Pazienza Valerio, de Gottardi Andrea, Rubbia-Brandt Laura, Conne Beatrice, Pugnale Paolo, Rossi Christine, Mangia Alessandra, Negro Francesco
Abstract excerpt
BACKGROUND/AIMS: The hepatitis C virus (HCV) induces lipid accumulation in vitro and in vivo. Although clinical observations are consistent with a direct effect of HCV genotype 3a on lipid metabolism, experimental systems have focused on the expression of HCV proteins of genotype 1. To extend these observations, we established an in vitro model expressing the HCV core of different genotypes. METHODS: The HCV core...
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