Article
Role of HCV Core gene of genotype 1a and 3a and host gene Cox-2 in HCV-induced pathogenesis.
Virology journal - 1 Apr 2011
Jahan Shah, Khaliq Saba, Ijaz Bushra, Ahmad Waqar, Hassan Sajida
Abstract excerpt
BACKGROUND: Hepatitis C virus (HCV) Core protein is thought to trigger activation of multiple signaling pathways and play a significant role in the alteration of cellular gene expression responsible for HCV pathogenesis leading to hepatocellular carcinoma (HCC). However, the exact molecular mechanism of HCV genome specific pathogenesis remains unclear. We examined the in vitro effects of HCV Core protein of HCV...
Topics
- Amino Acid Sequence
- Cell Line, Tumor
- Cyclooxygenase 2
- Down-Regulation
- Gene Expression Regulation
- Genotype
- Hepacivirus
- Hepatitis C
- Humans
- Molecular Sequence Data
- Sequence Alignment