Article
Hepatitis C virus nonstructural 4B protein modulates sterol regulatory element-binding protein signaling via the AKT pathway.
The Journal of biological chemistry - 3 Apr 2009
Park Chul-Yong, Jun Hyun-Jeong, Wakita Takaji, Cheong Jae Hun, Hwang Soon B
Abstract excerpt
Hepatitis C virus (HCV) infection is often associated with hepatic steatosis and yet the molecular mechanisms of HCV-associated steatosis are poorly understood. Because sterol regulatory element-binding proteins (SREBPs) are the major transcriptional factors in lipogenic gene expression including fatty acid synthase (FAS), we examined the effects of HCV nonstructural proteins on the signaling pathways of SREBP....
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