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Article

The SRE Motif in the Human PNPLA3 Promoter (-97 to -88 bp) Mediates Transactivational Effects of SREBP-1c.

Journal of cellular physiology - 1 Sept 2015

Liang Hua, Xu Jing, Xu Fen, Liu Hongxia, Yuan Ding, Yuan Shuhua, Cai Mengyin, Yan Jinhua, Weng Jianping

Abstract excerpt

Patatin-like phospholipase domain containing 3 (PNPLA3) is a non-secreted protein primarily expressed in liver and adipose tissue. Recently, numerous genetic studies have shown that PNPLA3 is a major susceptibility gene for nonalcoholic fatty liver disease (NAFLD). However, the mechanism involved in transcriptional regulation of the PNPLA3 gene remains unknown. We performed a detailed analysis of the human PNPLA3...

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Source

Identifiers

PMID: 25655569
DOI: 10.1002/jcp.24951

Genes

PNPLA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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