Article
Role of the insulin receptor substrate 1 and phosphatidylinositol 3-kinase signaling pathway in insulin-induced expression of sterol regulatory element binding protein 1c and glucokinase genes in rat hepatocytes.
Diabetes - 1 Jun 2002
Matsumoto Michihiro, Ogawa Wataru, Teshigawara Kiyoshi, Inoue Hiroshi, Miyake Kazuaki, Sakaue Hiroshi, Kasuga Masato
Abstract excerpt
The mechanism by which insulin induces the expression of the sterol regulatory element binding protein 1c (SREBP-1c) and glucokinase genes was investigated in cultured rat hepatocytes. Overexpression of an NH(2)-terminal fragment of IRS-1 that contains the pleckstrin homology and phosphotyrosine binding domains (insulin receptor substrate-1 NH(2)-terminal fragment [IRS-1N]) inhibited insulin-induced tyrosine...
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