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Article

Up-regulation of fatty acid synthase promoter by hepatitis C virus core protein: genotype-3a core has a stronger effect than genotype-1b core.

Journal of hepatology - 1 Jun 2007

Jackel-Cram Candice, Babiuk Lorne A, Liu Qiang

Abstract excerpt

BACKGROUND/AIMS: Hepatitis C virus genotype-3a (HCV-3a) is directly linked to steatosis development. We studied the effects of HCV-3a core protein on the promoter activity of fatty acid synthase (FAS), a major enzyme involved in de novo lipid synthesis. METHODS AND RESULTS: HCV-3a and -1b core genes were cloned and expressed. Using a FAS promoter-luciferase reporter, we demonstrated that both HCV-3a and -1b core...

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Share to Fatty Acid Synthases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Viral

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Share to Sequence Homology, Amino Acid

Share to Sterol Regulatory Element Binding Protein 1

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Source

Identifiers

PMID: 17188392
DOI: 10.1016/j.jhep.2006.10.019

Genes

FAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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