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mtDNA depletion confers specific gene expression profiles in human cells grown in culture and in xenograft

3 Nov 2008

Abstract excerpt

BACKGROUND: Interactions between the gene products encoded by the mitochondrial and nuclear genomes play critical roles in eukaryotic cellular function. However, the effects mitochondrial DNA (mtDNA) levels have on the nuclear transcriptome have not been defined under physiological conditions. In order to address this issue, we characterized the gene expression profiles of A549 lung cancer cells and their...

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PMID: 18980691
DOI: 10.1186/1471-2164-9-521

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