Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Progressive tumor features accompany epithelial-mesenchymal transition induced in mitochondrial DNA-depleted cells.

Cancer science - 1 Aug 2008

Naito Akihiro, Cook Cody C, Mizumachi Takatsugu, Wang Mian, Xie Cheng-Hui, Evans Teresa T, Kelly Thomas, Higuchi Masahiro

Abstract excerpt

The growth of LNCaP, a human prostate adenocarcinoma cell line, and MCF-7, a human breast adenocarcinoma cell line, is initially hormone dependent. We previously demonstrated that LNrho0-8 and MCFrho0, derived from LNCaP and MCF-7 by depleting mitochondrial DNA (mtDNA), exhibited hormone-independent growth that led to progressed phenotypes. Here, we demonstrate that LNrho0-8 and MCFrho0 have invasive characters...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cadherins
Share to Epithelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Vitro Techniques

Share to Mesoderm

Share to Pancreatic Neoplasms

Share to Receptors, Transforming Growth Factor beta

Share to Transforming Growth Factor beta

Share to Vimentin

Source

Open in PubMed Open full text

Identifiers

PMID: 18754870
DOI: 10.1111/j.1349-7006.2008.00879.x
PMCID: PMC2535852

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Progressive tumor features accompany epithelial-mesenchymal transition induced in mitochondrial DNA-depleted cells.PMID 18754870Read ↗

Progressive epithelial to mesenchymal transitions in ARCaP E prostate cancer cells during xenograft tumor formation and metastasis.Semantic proximity Read ↗

Progression of hormone-dependent adenocarcinoma cells to hormone-independent spindle carcinoma cells in vitro in a clonal spontaneous rat mammary tumor cell line.Semantic proximity Read ↗

Modulation of the malignant phenotype of human prostate cancer cells by N-(4-hydroxyphenyl)retinamide (4-HPR).Semantic proximity Read ↗

Epithelial to mesenchymal transition (EMT) in human prostate cancer: lessons learned from ARCaP model.Semantic proximity Read ↗

Combined inhibition of rho-associated protein kinase and EGFR suppresses the invasive phenotype in EGFR-dependent lung cancer cells.Semantic proximity Read ↗

Mitochondrial DNA mutation stimulates prostate cancer growth in bone stromal environment.Semantic proximity Read ↗

N-(4-hydroxyphenyl)retinamide (4-HPR) decreases neoplastic properties of human prostate cells: an agent for prevention.Semantic proximity Read ↗

mtDNA depletion confers specific gene expression profiles in human cells grown in culture and in xenograftSemantic proximity Read ↗

Cellular Migration and Invasion Uncoupled: Increased Migration Is Not an Inexorable Consequence of Epithelial-to-Mesenchymal TransitionSemantic proximity Read ↗

Effect of TGF-β mediated phenotypic changes on prostate cancer cell anoikis response.Semantic proximity Read ↗

Cytoskeletal organization and cell motility correlates with metastatic potential and state of differentiation in prostate cancer.Semantic proximity Read ↗

NF-κB–Dependent Plasticity of the Epithelial to Mesenchymal Transition Induced by <i>Von Hippel-Lindau</i> Inactivation in Renal Cell CarcinomasSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.