Article
Enhanced mtDNA repair capacity protects pulmonary artery endothelial cells from oxidant-mediated death.
American journal of physiology. Lung cellular and molecular physiology - 1 Jul 2002
Dobson Allison W, Grishko Valentina, LeDoux Susan P, Kelley Mark R, Wilson Glenn L, Gillespie Mark N
Abstract excerpt
In rat cultured pulmonary arterial (PA), microvascular, and venous endothelial cells (ECs), the rate of mitochondrial (mt) DNA repair is predictive of the severity of xanthine oxidase (XO)-induced mtDNA damage and the sensitivity to XO-mediated cell death. To examine the importance of mtDNA damage and repair more directly, we determined the impact of mitochondrial overexpression of the DNA repair enzyme, Ogg1, on...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.