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Article

Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth.

Molecular cancer therapeutics - 1 Feb 2010

Zhang Ping, Singh Anju, Yegnasubramanian Srinivasan, Esopi David, Kombairaju Ponvijay, Bodas Manish, Wu Hailong, Bova Steven G, Biswal Shyam

Abstract excerpt

Loss-of-function mutations in the nuclear factor erythroid-2-related factor 2 (Nrf2) inhibitor Kelch-like ECH-associated protein 1 (Keap1) result in increased Nrf2 activity in non-small cell lung cancer and confer therapeutic resistance. We detected point mutations in Keap1 gene, leading to nonconservative amino acid substitutions in prostate cancer cells. We found novel transcriptional and posttranscriptional...

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Identifiers

PMID: 20124447
DOI: 10.1158/1535-7163.MCT-09-0589
PMCID: PMC2821808

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth.PMID 20124447Read ↗

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