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Article

Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth.

Molecular cancer therapeutics - 1 Feb 2010

Zhang Ping, Singh Anju, Yegnasubramanian Srinivasan, Esopi David, Kombairaju Ponvijay, Bodas Manish, Wu Hailong, Bova Steven G, Biswal Shyam

Abstract excerpt

Loss-of-function mutations in the nuclear factor erythroid-2-related factor 2 (Nrf2) inhibitor Kelch-like ECH-associated protein 1 (Keap1) result in increased Nrf2 activity in non-small cell lung cancer and confer therapeutic resistance. We detected point mutations in Keap1 gene, leading to nonco...

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Identifiers

PMID: 20124447
DOI: 10.1158/1535-7163.MCT-09-0589
PMCID: PMC2821808

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20124447-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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