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Relationship of insulin-like growth factors system gene polymorphisms with the susceptibility and pathological development of hepatocellular carcinoma.

Annals of surgical oncology - 1 Jul 2010

Weng Chia-Jui, Hsieh Yi-Hsien, Tsai Chiung-Man, Chu Yin-Hung, Ueng Kwo-Chang, Liu Yu-Fan, Yeh Yuan-Hung, Su Shih-Chi, Chen Yi-Chen, Chen Mu-Kuan, Yang Shun-Fa

Abstract excerpt

BACKGROUND: Hepatocellular carcinoma (HCC) is one of the major causes of cancer-related death worldwide. The insulin-like growth factors (IGFs) system consists of a group of proteins which may induce cell proliferation and inhibit cell apoptosis through several signal pathways, leading to transformation of normal cells into cancer cells. However, the impact of genetic polymorphisms of the IGFs system on HCC has...

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PMID: 20119675
DOI: 10.1245/s10434-009-0904-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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