Article
Differences in the JAK2 and MPL mutation status in the cell lineages of the bcr/abl-negative chronic myeloproliferative neoplasm subtypes.
Internal medicine (Tokyo, Japan) - 1 Jan 2011
Toyama Kohtaro, Karasawa Masamitsu, Yokohama Akihiko, Mitsui Takeki, Uchiumi Hideki, Saitoh Takayuki, Handa Hiroshi, Murakami Hirokazu, Nojima Yoshihisa, Tsukamoto Norifumi
Abstract excerpt
OBJECTIVE: While the somatic mutation of Janus Kinase 2 (JAK2) and the thrombopoietin receptor (c-MPL) gene are thought to affect the pathogenesis of bcr/abl negative chronic myeloproliferative neoplasm (MPN), the relationship between the mutation and the clinical features remain obscure. METHODS: The mutation status of these genes in granulocytes, platelets, T-cells, and erythroid colonies (BFU-E) was obtained...
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