Article
Mutational status of myeloproliferative neoplasms.
Critical reviews in eukaryotic gene expression - 1 Jan 2010
Rumi Elisa, Elena Chiara, Passamonti Francesco
Abstract excerpt
Philadelphia negative myeloproliferative neoplasms include essential thrombocythemia, polycythemia vera, and primary myelofibrosis. Altered signaling is a hallmark of myeloproliferative neoplasms, as demonstrated by the presence of activating JAK2 (V617F) mutation in about 70% of patients (95% of polycythemia vera, 50%-60% of essential thrombocythemia, and 50%-60% of primary myelofibrosis). How a unique point...
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