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Article

Iron regulation of the major virulence factors in the AIDS-associated pathogen Cryptococcus neoformans.

PLoS biology - 1 Nov 2006

Jung Won Hee, Sham Anita, White Rick, Kronstad James W

Abstract excerpt

Iron overload is known to exacerbate many infectious diseases, and conversely, iron withholding is an important defense strategy for mammalian hosts. Iron is a critical cue for Cryptococcus neoformans because the fungus senses iron to regulate elaboration of the polysaccharide capsule that is the major virulence factor during infection. Excess iron exacerbates experimental cryptococcosis and the prevalence of...

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Identifiers

PMID: 17121456
DOI: 10.1371/journal.pbio.0040410
PMCID: PMC1637126

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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