Genetic and environmental factors causing variation in drug response.

doi:10.1016/0027-5107(91)90020-o

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Article

Genetic and environmental factors causing variation in drug response.

Mutation research - 1 Apr 1991

Vesell E S

Abstract excerpt

Large pharmacokinetic variations, ranging in magnitude from 4- to 40-fold, often exist among the members of a given population. These variations create differences in risk of cancer by accelerating metabolic activation of certain environmental carcinogens in some subjects, while retarding such ra...

Topics

Biotransformation
Cytochrome P-450 Enzyme System
Enzyme Induction
Humans
Liver
Neoplasms
Pedigree
Pharmacogenetics
Pharmacokinetics
Phenotype
Polymorphism, Genetic
Risk Factors
Twins

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