Multiple steps in carcinogenesis involving alterations of multiple tumor suppressor genes.

doi:10.1096/fasebj.7.10.8344488

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Article

Multiple steps in carcinogenesis involving alterations of multiple tumor suppressor genes.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 1993

Yokota J, Sugimura T

Abstract excerpt

Recent advances in molecular genetics have made it possible to understand the molecular mechanisms of human cancer progression. The results indicate that clinically evident tumor cells already carry multiple genetic alterations and further accumulation of genetic alteration occurs during tumor pr...

Topics

Animals
Genes, Tumor Suppressor
Humans
Mutation
Neoplasms

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