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Article

Cancer-associated mutations activate the nonreceptor tyrosine kinase Ack1.

The Journal of biological chemistry - 2 Apr 2010

Prieto-Echagüe Victoria, Gucwa Azad, Craddock Barbara P, Brown Deborah A, Miller W Todd

Abstract excerpt

Ack1 is a nonreceptor tyrosine kinase that participates in tumorigenesis, cell survival, and migration. Relatively little is known about the mechanisms that regulate Ack1 activity. Recently, four somatic missense mutations of Ack1 were identified in cancer tissue samples, but the effects on Ack1...

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Identifiers

PMID: 20110370
DOI: 10.1074/jbc.M109.060459
PMCID: PMC2856269

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20110370-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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