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Cancer associated talin point mutations disorganise cell adhesion and migration

11 Jan 2021

Abstract excerpt

Talin-1 is a key component of the multiprotein adhesion complexes which mediate cell migration, adhesion and integrin signalling and has been linked to cancer in several studies. We analysed talin-1 mutations reported in the Catalogue of Somatic Mutations in Cancer database and developed a bioinformatics pipeline to predict the severity of each mutation. These predictions were then assessed using biochemistry and...

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PMID: 33431906
DOI: 10.1038/s41598-020-77911-4

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