Article

Cancer associated talin point mutations disorganise cell adhesion and migration

2020-03-26

Abstract excerpt

Talin–1 is a key component of the multiprotein adhesion complexes which mediate cell migration, adhesion and integrin signalling and has been linked to cancer in several studies. We analysed talin–1 mutations reported in the COSMIC (Catalogue of Somatic Mutations in Cancer) database and developed a bioinformatics pipeline to predict the severity of each mutation. These predictions were then assessed using biochemi...

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Literature Corpus work: bc14c4ef-f5ac-5a56-b66a-ac73030d4ee6
DOI: 10.1101/2020.03.25.008193

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