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Article

Bosutinib inhibits migration and invasion via ACK1 in KRAS mutant non-small cell lung cancer.

Molecular cancer - 24 Jan 2014

Tan Daniel S W, Haaland Benjamin, Gan Jia Min, Tham Su Chin, Sinha Indrajit, Tan Eng Huat, Lim Kiat Hon, Takano Angela, Krisna Sai Sakktee, Thu Minn Minn Myint, Liew Hoe Peng, Ullrich Axel, Lim Wan-Teck, Chua Boon Tin

Abstract excerpt

The advent of effective targeted therapeutics has led to increasing emphasis on precise biomarkers for accurate patient stratification. Here, we describe the role of ACK1, a non-receptor tyrosine kinase in abrogating migration and invasion in KRAS mutant lung adenocarcinoma. Bosutinib, which inhibits ACK1 at 2.7 nM IC50, was found to inhibit cell migration and invasion but not viability in a panel of non-small...

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Identifiers

PMID: 24461128
DOI: 10.1186/1476-4598-13-13
PMCID: PMC3930897

Genes

KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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