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ACK1/TNK2 kinase: molecular mechanisms and emerging cancer therapeutics

24 Dec 2024

Abstract excerpt

Activated CDC42-associated kinase 1 (ACK1), encoded by the TNK2 gene, is a cytoplasmic non-receptor tyrosine kinase whose aberrant activation correlates positively with cancer severity. Recent research has revealed the functional relevance of this oncokinase - it is an epigenetic regulator that drives cancer progression in multiple malignancies. Although ACK1 is an attractive target for therapeutic intervention,...

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PMID: 39721828
DOI: 10.1016/j.tips.2024.11.006

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