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Biochemical Studies of Systemic Lupus Erythematosus-Associated Mutations in Nonreceptor Tyrosine Kinases Ack1 and Brk.

Biochemistry - 21 Mar 2023

Kan Yagmur, Paung YiTing, Kim Yunyoung, Seeliger Markus A, Miller W Todd

Abstract excerpt

Tyrosine kinases (TKs) play essential roles in signaling processes that regulate cell survival, migration, and proliferation. Dysregulation of tyrosine kinases underlies many disorders, including cancer, cardiovascular and developmental diseases, as well as pathologies of the immune system. Ack1 and Brk are nonreceptor tyrosine kinases (NRTKs) best known for their roles in cancer. Here, we have biochemically...

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PMID: 36854171
DOI: 10.1021/acs.biochem.2c00685
PMCID: PMC10052838

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