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Article

Arrest defective-1 controls tumor cell behavior by acetylating myosin light chain kinase.

PloS one - 14 Oct 2009

Shin Dong Hoon, Chun Yang-Sook, Lee Kyoung-Hwa, Shin Hyun-Woo, Park Jong-Wan

Abstract excerpt

BACKGROUND: The enhancement of cell motility is a critical event during tumor cell spreading. Since myosin light chain kinase (MLCK) regulates cell behavior, it is regarded as a promising target in terms of preventing tumor invasion and metastasis. Since MLCK was identified to be associated with human arrest defective-1 (hARD1) through yeast two-hybrid screening, we here tested the possibility that hARD1 acts as...

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Identifiers

PMID: 19826488
DOI: 10.1371/journal.pone.0007451
PMCID: PMC2758594

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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