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Article

Non-autonomous insulin signaling delays mitotic progression in C. elegans germline stem and progenitor cells.

PLoS genetics - 1 Dec 2024

Cheng Eric, Lu Ran, Gerhold Abigail R

Abstract excerpt

Stem and progenitor cell mitosis is essential for tissue development and homeostasis. How these cells ensure proper chromosome segregation, and thereby maintain mitotic fidelity, in the complex physiological environment of a living animal is poorly understood. Here we use in situ live-cell imaging of C. elegans germline stem and progenitor cells (GSPCs) to ask how the signaling environment influences stem and...

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PMID: 39715269
DOI: 10.1371/journal.pgen.1011351
PMCID: PMC11706408

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