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Article

Crumbs, Moesin and Yurt regulate junctional stability and dynamics for a proper morphogenesis of the Drosophila pupal wing epithelium.

Scientific reports - 1 Dec 2017

Salis Pauline, Payre Francois, Valenti Philippe, Bazellieres Elsa, Le Bivic André, Mottola Giovanna

Abstract excerpt

The Crumbs (Crb) complex is a key epithelial determinant. To understand its role in morphogenesis, we examined its function in the Drosophila pupal wing, an epithelium undergoing hexagonal packing and formation of planar-oriented hairs. Crb distribution is dynamic, being stabilized to the subapical region just before hair formation. Lack of crb or stardust, but not DPatj, affects hexagonal packing and delays hair...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29196707
DOI: 10.1038/s41598-017-15272-1
PMCID: PMC5711895

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Crumbs, Moesin and Yurt regulate junctional stability and dynamics for a proper morphogenesis of the Drosophila pupal wing epithelium.PMID 29196707Read ↗

Crumbs and stardust act in a genetic pathway that controls the organization of epithelia in Drosophila melanogaster.Semantic proximity Read ↗

Crumbs, the Drosophila homologue of human CRB1/RP12, is essential for photoreceptor morphogenesis.Semantic proximity Read ↗

Drosophila Crumbs is a positional cue in photoreceptor adherens junctions and rhabdomeres.Semantic proximity Read ↗

Multiple domains of Stardust differentially mediate localisation of the Crumbs-Stardust complex during photoreceptor development in Drosophila.Semantic proximity Read ↗

Mosaic Eyes is a novel component of the Crumbs complex and negatively regulates photoreceptor apical size.Semantic proximity Read ↗

Yurt, Coracle, Neurexin IV and the Na(+),K(+)-ATPase form a novel group of epithelial polarity proteins.Semantic proximity Read ↗

Crumbs controls epithelial integrity by inhibiting Rac1 and PI3K.Semantic proximity Read ↗

crumbs and stardust, two genes of Drosophila required for the development of epithelial cell polarity.Semantic proximity Read ↗

Epithelial polarity proteins regulate Drosophila tracheal tube size in parallel to the luminal matrix pathway.Semantic proximity Read ↗

Crumbs promotes expanded recognition and degradation by the SCF(Slimb/β-TrCP) ubiquitin ligase.Semantic proximity Read ↗

crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia.Semantic proximity Read ↗

The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded.Semantic proximity Read ↗

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