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Article

Down syndrome fibroblasts and mouse Prep1-overexpressing cells display increased sensitivity to genotoxic stress.

Nucleic acids research - 1 Jun 2010

Micali Nicola, Longobardi Elena, Iotti Giorgio, Ferrai Carmelo, Castagnaro Laura, Ricciardi Mario, Blasi Francesco, Crippa Massimo P

Abstract excerpt

PREP1 (PKNOX1) maps in the Down syndrome (DS) critical region of chromosome 21, is overexpressed in some DS tissues and might be involved in the DS phenotype. By using fibroblasts from DS patients and by overexpressing Prep1 in F9 teratocarcinoma and Prep1(i/i) MEF to single out the role of the p...

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Identifiers

PMID: 20110257
DOI: 10.1093/nar/gkq019
PMCID: PMC2887940

Genes

PKNOX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20110257-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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