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Article

Prep1 deficiency induces protection from diabetes and increased insulin sensitivity through a p160-mediated mechanism.

Molecular and cellular biology - 1 Sept 2008

Oriente Francesco, Fernandez Diaz Luis Cesar, Miele Claudia, Iovino Salvatore, Mori Silvia, Diaz Victor Manuel, Troncone Giancarlo, Cassese Angela, Formisano Pietro, Blasi Francesco, Beguinot Francesco

Abstract excerpt

We have examined glucose homeostasis in mice hypomorphic for the homeotic transcription factor gene Prep1. Prep1-hypomorphic (Prep1(i/i)) mice exhibit an absolute reduction in circulating insulin levels but normal glucose tolerance. In addition, these mice exhibit protection from streptozotocin-induced diabetes and enhanced insulin sensitivity with improved glucose uptake and insulin-dependent glucose disposal by...

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Source

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Identifiers

PMID: 18644868
DOI: 10.1128/MCB.00117-08
PMCID: PMC2546928

Genes

PGC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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