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Article

Reduction of Prep1 levels affects differentiation of normal and malignant B cells and accelerates Myc driven lymphomagenesis.

PloS one - 1 Jan 2012

Iotti Giorgio, Mejetta Stefania, Modica Livia, Penkov Dmitry, Ponzoni Maurilio, Blasi Francesco

Abstract excerpt

The Prep1 homeodomain transcription factor has recently been recognized as a tumor suppressor. Among other features, haploinsufficiency of Prep1 is able to strongly accelerate the B-lymphomagenesis in EμMyc mice. Now we report that this occurs concomitantly with a change in the type of B-cell lymphomas generated by the Myc oncogene. Indeed, the tumors generated in the EμMyc-Prep1(+/-) mice are much more immature,...

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Source

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Identifiers

PMID: 23133585
DOI: 10.1371/journal.pone.0048353
PMCID: PMC3485025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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