Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcription factor PREP1 induces EMT and metastasis by controlling the TGF-β–SMAD3 pathway in non-small cell lung adenocarcinoma

25 Aug 2014

Abstract excerpt

Pre-B-cell leukemia homeobox (Pbx)-regulating protein-1 (Prep1) is a ubiquitous homeoprotein involved in early development, genomic stability, insulin sensitivity, and hematopoiesis. Previously we have shown that Prep1 is a haploinsufficient tumor suppressor that inhibits neoplastic transformation by competing with myeloid ecotropic integration site 1 for binding to the common heterodimeric partner Pbx1....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer-related gene regulation
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25157139
DOI: 10.1073/pnas.1407074111

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcription factor PREP1 induces EMT and metastasis by controlling the TGF-β–SMAD3 pathway in non-small cell lung adenocarcinomaPMID 25157139Read ↗

A tale of TALE, PREP1, PBX1, and MEIS1: Interconnections and competition in cancer.Semantic proximity Read ↗

Prep1 (pKnox1)‐deficiency leads to spontaneous tumor development in mice and accelerates EμMyc lymphomagenesis: A tumor suppressor role for Prep1Semantic proximity Read ↗

PSPC1 mediates TGF-β1 autocrine signalling and Smad2/3 target switching to promote EMT, stemness and metastasis.Semantic proximity Read ↗

Widespread FRA1-Dependent Control of Mesenchymal Transdifferentiation Programs in Colorectal Cancer CellsSemantic proximity Read ↗

PMEPA1 induces EMT via a non‐canonical TGF‐β signalling in colorectal cancerSemantic proximity Read ↗

Cripto-1: An Embryonic Gene That Promotes TumorigenesisSemantic proximity Read ↗

Paired related homoeobox 1, a new EMT inducer, is involved in metastasis and poor prognosis in colorectal cancerSemantic proximity Read ↗

The cell-penetrating FOXM1 N-terminus (M1-138) demonstrates potent inhibitory effects on cancer cells by targeting FOXM1 and FOXM1-interacting factor SMAD3Semantic proximity Read ↗

NKX6.1 functions as a metastatic suppressor through epigenetic regulation of the epithelial–mesenchymal transitionSemantic proximity Read ↗

Engrailed‐1 Promotes Pancreatic Cancer MetastasisSemantic proximity Read ↗

TGFβ and EGF signaling orchestrates the AP-1- and p63 transcriptional regulation of breast cancer invasivenessSemantic proximity Read ↗

A Truncated Snail1 Transcription Factor Alters the Expression of Essential EMT Markers and Suppresses Tumor Cell Migration in a Human Lung Cancer Cell LineSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.