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Article

HIV sequence variation associated with env antisense adoptive T-cell therapy in the hNSG mouse model.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Apr 2010

Mukherjee Rithun, Plesa Gabriela, Sherrill-Mix Scott, Richardson Max W, Riley James L, Bushman Frederic D

Abstract excerpt

The first use of lentiviral vectors in humans involved transduction of mature T-cells with an human immunodeficiency virus (HIV)-derived env antisense (envAS) vector to protect cells from HIV infection. In that study, only a minority of the patient T-cell population could be gene-modified, raisin...

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Share to env Gene Products, Human Immunodeficiency Virus
Share to Immunotherapy, Adoptive

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred NOD

Share to Mice, SCID

Share to RNA, Antisense

Share to T-Lymphocytes

Share to Transduction, Genetic

Share to Virus Replication

Source

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Identifiers

PMID: 20104212
DOI: 10.1038/mt.2009.316
PMCID: PMC2862538

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20104212-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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