Article

Human-like NSG mouse glycoproteins sialylation pattern changes the phenotype of human lymphocytes and sensitivity to HIV-1 infection

2018-08-31

Abstract excerpt

<h4>Background</h4> The use of immunodeficient mice transplanted with human hematopoietic stem cells is an accepted approach to study human-specific infectious diseases, like HIV-1, and to investigate multiple aspects of human immune system development. However, mouse and human are different in sialylation patterns of proteins due to evolutionary mutations of the CMP-N-acetylneuraminic acid hydroxylase ( CMAH )...

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Literature Corpus work: 2def837b-a33c-54cc-83e2-26b9c5071d82
DOI: 10.1101/404905

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