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Article

Apobec-mediated retroviral hypermutation in vivo is dependent on mouse strain.

PLoS pathogens - 1 Aug 2024

Byun Hyewon, Singh Gurvani B, Xu Wendy Kaichun, Das Poulami, Reyes Alejandro, Battenhouse Anna, Wylie Dennis C, Santiago Mario L, Lozano Mary M, Dudley Jaquelin P

Abstract excerpt

Replication of the complex retrovirus mouse mammary tumor virus (MMTV) is antagonized by murine Apobec3 (mA3), a member of the Apobec family of cytidine deaminases. We have shown that MMTV-encoded Rem protein inhibits proviral mutagenesis by the Apobec enzyme, activation-induced cytidine deaminase (AID) during viral replication in BALB/c mice. To further study the role of Rem in vivo, we have infected C57BL/6...

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Identifiers

PMID: 39208378
DOI: 10.1371/journal.ppat.1012505
PMCID: PMC11389910

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