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Breast Tumor Heterogeneity: Cancer Stem Cells or Clonal Evolution?

1 Oct 2007

Abstract excerpt

Breast tumors are composed of a variety of cell types with distinct morphologies and behaviors. It is not clear how this tumor heterogeneity comes about. Two popular concepts that attempt to explain this are the cancer stem cell hypothesis and the clonal evolution model. Each of these ideas has been investigated for some time, leading to the accumulation of numerous findings that are used to support one or the...

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PMID: 17786053
DOI: 10.4161/cc.6.19.4914

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