Article
Ductal carcinoma in situ and the emergence of diversity during breast cancer evolution.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2008
Allred D Craig, Wu Yun, Mao Sufeng, Nagtegaal Iris D, Lee Sangjun, Perou Charles M, Mohsin Syed K, O'Connell Peter, Tsimelzon Anna, Medina Dan
Abstract excerpt
PURPOSE: Human invasive breast cancers (IBC) show enormous histologic and biological diversity. This study comprehensively evaluated diversity in ductal carcinoma in situ (DCIS), the immediate precursors of IBCs. EXPERIMENTAL DESIGN: The extent of diversity for conventional histologic grade and standard prognostic biomarkers assessed by immunohistochemistry was evaluated in a series of pure DCIS (n = 200)...
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