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Breast cancer: origins and evolution

1 Nov 2007

Abstract excerpt

Breast cancer is not a single disease, but rather is composed of distinct subtypes associated with different clinical outcomes. Understanding this heterogeneity is key for the development of targeted cancer-preventative and -therapeutic interventions. Current models explaining inter- and intratumoral diversity are the cancer stem cell and the clonal evolution hypotheses. Although tumor initiation and progression...

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PMID: 17975657
DOI: 10.1172/jci33295

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