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Preclinical validation of a microarray method for full molecular karyotyping of blastomeres in a 24-h protocol

24 Jan 2010

Abstract excerpt

BACKGROUND: Preimplantation genetic screening (PGS) has been used in an attempt to determine embryonic aneuploidy. Techniques that use new molecular methods to determine the karyotype of an embryo are expanding the scope of PGS. METHODS: We introduce a new method for PGS, termed 'parental support', which leverages microarray measurements from parental DNA to 'clean' single-cell microarray measurements on...

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PMID: 20100701
DOI: 10.1093/humrep/dep452

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