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Article

Preclinical validation of a targeted next generation sequencing-based comprehensive chromosome screening methodology in human blastocysts

22 Nov 2017

Abstract excerpt

STUDY QUESTION: Can a novel targeted next generation sequencing (tNGS) platform accurately detect whole chromosome aneuploidy in a trophectoderm biopsy and provide additional information to improve testing? SUMMARY ANSWER: Karyotypes obtained by tNGS were concordant with other validated platforms and single nucleotide polymorphism genotyping information obtained can be used for improved detection and quality...

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PMID: 29186554
DOI: 10.1093/molehr/gax060

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