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Article

Two multiplex assays that simultaneously identify 22 possible mutation sites in the KRAS, BRAF, NRAS and PIK3CA genes.

PloS one - 21 Jan 2010

Lurkin Irene, Stoehr Robert, Hurst Carolyn D, van Tilborg Angela A G, Knowles Margaret A, Hartmann Arndt, Zwarthoff Ellen C

Abstract excerpt

Recently a number of randomized trials have shown that patients with advanced colorectal cancer do not benefit from therapies targeting the epidermal growth factor receptor when their tumors harbor mutations in the KRAS, BRAF and PIK3CA genes. We developed two multiplex assays that simultaneously...

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Source

Open in PubMed Open full text

Identifiers

PMID: 20098682
DOI: 10.1371/journal.pone.0008802
PMCID: PMC2809099

Genes

KRAS
BRAF
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20098682-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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