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Article

KRAS, NRAS, PIK3CA exon 20, and BRAF genotypes in synchronous and metachronous primary colorectal cancers diagnostic and therapeutic implications.

The Journal of molecular diagnostics : JMD - 1 Jul 2011

Balschun Katharina, Haag Jochen, Wenke Ann-Kathrin, von Schönfels Witigo, Schwarz Nicolas T, Röcken Christoph

Abstract excerpt

Targeted therapy of advanced colorectal carcinoma (CRC) necessitates KRAS genotyping. Because we were interested in diagnostic and therapeutic consequences, we studied the KRAS, NRAS, PIK3CA exon 20, and BRAF genotypes in synchronous and metachronous primary CRCs; in addition, we studied their available metastases. We studied 21 patients with 43 synchronous and 2 metachronous adenocarcinomas of the colorectum (n...

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Source

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Identifiers

PMID: 21704278
DOI: 10.1016/j.jmoldx.2011.03.002
PMCID: PMC3123804

Genes

KRAS
BRAF
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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